- Christoph Cremer
Supramolecular structures to the cell, nuclear genome, cell biology, biomolecular machines, radiation biology, image analysis, biophotonics, flow cytometry, light optical microscopy and nanoscopy, computer modelling of nuclear genome structure.
- Jürgen Debus
Radiation oncology, precision radiotherapy, ion beam radiotherapy, radiation biology
- Michael Grunze
Biocompatible surface coatings, adhesion science, self assembly of organic mono- and multilayers, non-linear optical laser spectroscopy on surfaces, photoemission, x-ray absorption and x-ray emission spectroscopy, x-ray microscopy, protein and cell interactions with artificial surfaces, protein adsorption kinetics, protein resistant and inert surfaces, cell adhesion, acoustic and optical biosensors, theory of biomolecule/surface interactions, x-ray microanalysis of biological tissue, biophysical aspects of glaucoma
- Fred A. Hamprecht
The recording of vast amounts of data has become a characteristic of our time and can be observed in areas ranging from medicine and systems biology to industrial quality control, the security sector, and financial markets. In these areas, an individual object is often described by multiple features, giving rise to "multivariate data". We are interested in all aspects of the (semi-) automatic analysis of such data, with the aim of leveraging its information content. In particular, we develop methods for the analysis of contiguous data with more than two dimensions, such as spectral images. In addition, we deploy methods from signal processing, image processing and (un-) supervised learning. Our principal application is in the development of automated diagnostic systems in medicine, biology and industrial quality control.
- Michael Hausmann
Nuclear genome, cell biology, biomolecular machines, image analysis, biophotonics, flow cytometry, light optical microscopy and nanoscopy.
- Dieter W. Heermann
The group is working mainly in the field of Theoretical Biophysics but still has close ties to the polymer physics world. The group develops and applies computational techniques for modeling and understanding biological processes at the molecular level. Our research emphasizes the application of statistical physics techniques, such as Markov models, Monte Carlo and molecular dynamics techniques as well as bayesian analysis techniques. We apply these techniques to various types of biological problems and data, including the modeling of the dynamic structure of chromosomes on large scales, DNA and protein sequence data, as well as gene expression data from microarray experiments. The group is at the forefront of modeling and simulation and is working very closely with experimental biologists and physicists in building useful models of biological phenomena from the molecular level to the cellular levels.
- Stefan W. Hell
Establishing nanoscale resolution (beyond the diffraction barrrier) with visible focused light and its application to biology. STED-microscopy, 4Pi-microscopy, RESOLFT type of microscopes with diffraction-unlimited spatial resolution.
- Jörg Langowski
The research focus of our lab at the DKFZ is the three-dimensional organization of the genome in normal and tumor cells and to describe it by quantitative models. This will help us understand the connection between genome structure and normal or pathological states of the cell. To this aim, we study long-range interactions in DNA when genes are regulated by transcription factors, the structure of nucleosomes and chromatin fiber, and the organization of chromosome territories. The experiments are supplemented by advanced computer simulation techniques that describe the organization of DNA and chromatin in the cell as a flexible polymer. Biophysical methods in our research program include first and foremost single-molecule techniques (fluorescence correlation spectroscopy, single pair FRET, scanning force microscopy), but also dynamic light scattering, neutron scattering, analytical ultracentrifugation, absorption and fluorescence spectroscopy, and stopped flow kinetics. We also develop and provide biophysical techniques for the characterization of other systems of biological macromolecules, especially in protein-protein and protein-DNA interaction and intermediate filament proteins.
- Volker Lindenstruth
The main focus of the group is the application of computer science in the field of physics, in particular in high-performance trigger, tracking and readout systems. For instance, the group is developing a high-level trigger processor, which is capable of performing a full event reconstruction on a 25 GB/sec data stream in real time. This PC-Cluster is scheduled for first operation in 2007 and will implement about 1000 COTS processors. The group is also developing infrastructures for autonomous PC clusters, which are seen as building blocks for new GRID systems, as well as for high-performance clusters for scientific computing. The event reconstruction of physics experiments require significant effort in simulation and modelling.
- Reinhard Männer
Application-specific processors, reconfigurable computing, real-time pattern recognition and image processing, interactive visualization, computational medicine, virtual reality.
- Karlheinz Meier
Research on analog and mixed-signal VLSI systems emulating the neural microcircuit.
Experimental study of bio-inspired computing concepts in the framework of the European FACETS consortium. - Jean Francois Nedelec
Mechanisms and principles that underlie the organisation of the different compartments and the distribution of specific molecules to each cellular sub-system.
- Uwe Oelfke
Radiation therapy, dose distribution, intensity-modulated radiation therapy (IMRT) with inverse therapy planning, developing methods for recording and controlling position changes of irradiated tissues during treatment.
- Annemarie Pucci
Dynamics of complex condensed matter systems, atomic force microscopy,spectroscopy in the IR region.
- Karsten Rippe
Regulation of transcription by changes of the chromatin conformation, analysis of chromatin conformation by scanning/atomic force microscopy and fluorescence microscopy, modeling chromatin fibers by Monte Carlo procedures and analytical descriptions, mobility and interactions of chromatin modifying complexes studied by new fluorescence fluctuation spectroscopy methods, DNA sequence directed positioning of nucleosomes by chromatin remodelers.
- Lothar Schad
Improved oncological radiotherapy treatment planning and monitoring by using physiological and functional imaging of CT, MRI and PET. Developing of new MR techniques (3D FLASH, dynamic MRT, diffusion, perfusion, MRA, blood bolus tagging, BOLD MRI) for clinical use in therapy planning and monitoring . Imaging of hyperpolarized 3He in the human lung, techniques (T2*- and T1-technique) for non-invasive measuring of tissue oxygenation and perfusion in the myocardium and with general interest in oncology.
- Wolfgang Schlegel
Radiation therapy, dose distribution, intensity-modulated radiation therapy (IMRT) with inverse therapy planning, developing methods for recording and controlling position changes of irradiated tissues during treatment.
- Ilme Schlichting
Flavin-based Photoreceptors, Heme Thiolate enzyme, crystallography, quantum chemical calculations, steady state and transient kinetics, fluorescence spectroscopy, mass spectroscopy, ITC, light scattering, biochemistry, molecular biology.
- Ulrich Schwarz
Forces and elasticity in cell-matrix adhesion, use of elastic substrates to measure cellular forces, L-selectin mediated tethering and rolling of white blood cells in shear flow, hollow nanoparticles, amphiphilic self-assembly, bicontinuous cubic phases, triply periodic minimal surfaces.
- Wolfhard H. Semmler
Development of new methods and devices, respectively in magnetic resonance imaging, positron emission tomography, single photon emission tomomography, optical tomography, and interventional MRI, contrast media research, molecular imaging research.
- Irmgard Sinning
Our group is working on two major topics: biogenesis and characterization of membrane proteins and a detailed understanding of the targeting/insertion machinery of the signal recognition particle.
- Jeremy C. Smith
Protein vibrations and hydration, neutron and X-ray scattering protein glass transition enzyme dynamics and activity.
- Joachim Spatz
Materials sciences, physics of soft matter, biophysics, non-conventional nanolithography, biofunctionalisation of solid and soft interfaces.
- Ernst H.K. Stelzer
The group has contributed extensively to the developments in Confocal Fluorescence Microscopy and its applications in the modern life sciences. Long standing interests are the development of laser-based instruments and applications that are related to the observation and the manipulation of large biological specimens such as e.g. fish and insect embryos as well as investigations on the level of single molecules that are maintained under physiologically relevant conditions. es.
- Motomu Tanaka
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